"Because treatment of acute uncomplicated cystitis is usually empirical, it is likely that some women will be treated with a drug that does not have in vitro activity against the uropathogen. As the population resistance prevalence of a specific agent increases, the likelihood of failure outweighs the benefits of using the drug empirically."
Infections are the #1 cause for hospital readmissions generating a 62% rate of 30-day readmissions, more than 1.1 million/year (14) costing U.S. hospitals more than $2 billion, annually(15).
It is now the leading cause of death in U.S. hospitals (3) costing $24 billion per year,(4)
The Centers for Disease Control estimates 2 million Americans are afflicted annually by antibiotic-resistant pathogens (2).
More than 1.6 million U.S. adults develop sepsis (22).
There are 20-30 million bacterial blood cultures performed annually in the U.S, alone (24).
Bloodstream infections now take more lives than HIV, breast cancer and prostate cancer combined (13).
Over 258,000 people die from antibiotic resistant bacterial sepsis every year in the U.S., one every 2 minutes (23)
Infections affect over 26 million people annually, and is the largest killer of children (> 5 million children/yr)(5).
The total economic burden placed on the U.S. economy by antibiotic resistant infections has been estimated to be as high as $20 billion in health care costs and $35 billion a year in lost productivity (25).
According to a 2019 study published in JAMA, records of 568 patients from six U.S. hospitals who either died in the hospital or who were discharged to hospice , showed sepsis was present in more than half (300) of the hospitalizations and directly caused death in more than one-third (198) of cases.(9)
100 million UTI tests are performed annually costing $billions in healthcare costs (1).
In the U.S., there are an estimated 10.5 million U.S. office visits for UTIs where antibiotic sensitivity testing could be performed.(1).
UTIs are one of the leading causes of ER visits, cost over $4-billion annually.(12)
Approximately forty percent (40%) of all nosocomial (hospital acquired) infections are UTIs with more than 1 million catheter-associated UTIs/year in the U.S. alone(21).
Fifty percent (50%) of the U.S. population suffers from a UTI at least once in their lifetime(19).
80% of women will contract a UTI13 and 20%-30% of these women will suffer from recurring bouts of UTIs (18) throughout their lifetimes.
Of the 150 million UTI’s per year worldwide(16)
The following statistics relate to the prevalence of Urinary tract infections:
The following statistics relate to the incidence of Urinary tract infections:
Physician office visits for Urinary tract infections: 9.1 million visits were made to physician offices regarding urinary tract infections in the US 2000 (Weighted Analysis of 1999 NAMCS, 2003, NIDDK)
The following are statistics from various sources about physician office visits and Urinary tract infections:
Physician office visits for Urinary tract infections: In the United States, urinary track infections (UTIs) account for about 4 million ambulatory-care visits each year, representing about 1% of all outpatient visits. (Source: excerpt from Urinary Tract Infections: DBMD)
The following are statistics from various sources about hospitalizations and Urinary tract infections:
Hospitalizations for Urinary tract infections: